The leading cause of death in HIV-infected individuals.
Weakened immune system
Limits sensitivity of diagnosis of TB
Support vector machine to find 251-gene signature
Genes involved in Immunological, Infectious and Inflammatory Disease
Limits sensitivity of diagnosis of TB
Our aim:
Explore genes with a significant expression enriched in HIV with TB co-infection
Compare with the 251-gene signature found with the SVM model
Data origin
Purpose of data collection
Data handling Remove irrelevant variables Change ugly variables Handle replications
Discriptive analysis
Normalization Log2
First PC explains 15% of the variance
31 PCs needed to explain 90% of variance
Forest plot
Volcano plot